Pulmonary Arterial Hypertension FAQs
What are the signs and symptoms of pulmonary arterial hypertension?
Common symptoms of PAH include:
- Dyspnea (shortness of breath)
- Chest pain
- Fainting episodes
- Abdomen pain on the upper right side
- A reduced appetite
- An accelerated heartbeat
PAH is a progressive disease and until the severity of its symptoms worsen, some individuals may go years without knowing they have PAH. In general, symptoms can be mild, nonspecific, or present only when the individual is heavily exercising.
What causes pulmonary arterial hypertension?
The cause of PAH remains unknown. PAH can be inherited (15-20% of cases).
How is pulmonary arterial hypertension treated?
There is no current cure for PAH; however, it can be treated. It is vital to treat PAH because high blood pressure in the lungs forces the right side of the heart to work overtime. Over extended periods of time, this can cause the heart muscle to weaken, or heart failure.
Are there tests available that can detect pulmonary arterial hypertension?
During a physical exam, to check for PAH, the doctor will listen to the heart and lungs with a stethoscope. They also examine ankles and legs for swelling and the lips and skin for a bluish tint. If the doctor wishes to conduct further testing to confirm a PAH diagnosis, they may recommend an echocardiogram, a chest x-ray, an EKG, or a right heart catheterization.
Who is most at risk for pulmonary arterial hypertension?
PAH usually affects women 30-60 years of age. About 15-20% of individuals with PAH have inherited it. PAH is also associated with several other medical diseases including cirrhosis and connective tissue diseases such as scleroderma. Approximately 30% of patients diagnosed with PAH also have a connective tissue disease.
What is the prognosis for individuals affected by pulmonary arterial hypertension?
PAH is progressive. Therefore, the individual may only have mild symptoms of the disease at the start. As the disease progresses, the individual will eventually need treatment and medical care to live a normal lifestyle.
What is the purpose of this study?
To assess the safety, tolerability, pharmacokinetics, and efficacy of QCC374 in the treatment of pulmonary arterial hypertension.